Pesquisa | BVS Odontologia

1.

Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses.

Alameh, Mohamad-Gabriel; Tombácz, István; Bettini, Emily; Lederer, Katlyn; Sittplangkoon, Chutamath; Wilmore, Joel R; Gaudette, Brian T; Soliman, Ousamah Y; Pine, Matthew; Hicks, Philip; Manzoni, Tomaz B; Knox, James J; Johnson, John L; Laczkó, Dorottya; Muramatsu, Hiromi; Davis, Benjamin; Meng, Wenzhao; Rosenfeld, Aaron M; Strohmeier, Shirin; Lin, Paulo J C; Mui, Barbara L; Tam, Ying K; Karikó, Katalin; Jacquet, Alain; Krammer, Florian; Bates, Paul; Cancro, Michael P; Weissman, Drew; Luning Prak, Eline T; Allman, David; Locci, Michela; Pardi, Norbert.

Immunity ; 54(12): 2877-2892.e7, 2021 12 14.

Artigo em Inglês | MEDLINE | ID: mdl-34852217

2.

SARS-CoV-2 mRNA Vaccines Foster Potent Antigen-Specific Germinal Center Responses Associated with Neutralizing Antibody Generation.

Lederer, Katlyn; Castaño, Diana; Gómez Atria, Daniela; Oguin, Thomas H; Wang, Sidney; Manzoni, Tomaz B; Muramatsu, Hiromi; Hogan, Michael J; Amanat, Fatima; Cherubin, Patrick; Lundgreen, Kendall A; Tam, Ying K; Fan, Steven H Y; Eisenlohr, Laurence C; Maillard, Ivan; Weissman, Drew; Bates, Paul; Krammer, Florian; Sempowski, Gregory D; Pardi, Norbert; Locci, Michela.

Immunity ; 53(6): 1281-1295.e5, 2020 12 15.

Artigo em Inglês | MEDLINE | ID: mdl-33296685

3.

IL7 increases targeted lipid nanoparticle-mediated mRNA expression in T cells in vitro and in vivo by enhancing T cell protein translation.

Tilsed, Caitlin M; Sadiq, Barzan A; Papp, Tyler E; Areesawangkit, Phurin; Kimura, Kenji; Noguera-Ortega, Estela; Scholler, John; Cerda, Nicholas; Aghajanian, Haig; Bot, Adrian; Mui, Barbara; Tam, Ying; Weissman, Drew; June, Carl H; Albelda, Steven M; Parhiz, Hamideh.

Proc Natl Acad Sci U S A ; 121(13): e2319856121, 2024 Mar 26.

Artigo em Inglês | MEDLINE | ID: mdl-38513098

4.

Throughput-scalable manufacturing of SARS-CoV-2 mRNA lipid nanoparticle vaccines.

Shepherd, Sarah J; Han, Xuexiang; Mukalel, Alvin J; El-Mayta, Rakan; Thatte, Ajay S; Wu, Jingyu; Padilla, Marshall S; Alameh, Mohamad-Gabriel; Srikumar, Neha; Lee, Daeyeon; Weissman, Drew; Issadore, David; Mitchell, Michael J.

Proc Natl Acad Sci U S A ; 120(33): e2303567120, 2023 08 15.

Artigo em Inglês | MEDLINE | ID: mdl-37556502

5.

Targeting lipid nanoparticles to the blood-brain barrier to ameliorate acute ischemic stroke.

Nong, Jia; Glassman, Patrick M; Shuvaev, Vladimir V; Reyes-Esteves, Sahily; Descamps, Helene C; Kiseleva, Raisa Y; Papp, Tyler E; Alameh, Mohamad-Gabriel; Tam, Ying K; Mui, Barbara L; Omo-Lamai, Serena; Zamora, Marco E; Shuvaeva, Tea; Arguiri, Evguenia; Gong, Xijing; Brysgel, Taylor V; Tan, Ai Wen; Woolfork, Ashley G; Weljie, Aalim; Thaiss, Christoph A; Myerson, Jacob W; Weissman, Drew; Kasner, Scott E; Parhiz, Hamideh; Muzykantov, Vladimir R; Brenner, Jacob S; Marcos-Contreras, Oscar A.

Mol Ther ; 32(5): 1344-1358, 2024 May 01.

Artigo em Inglês | MEDLINE | ID: mdl-38454606

6.

In Vivo mRNA CAR T Cell Engineering via Targeted Ionizable Lipid Nanoparticles with Extrahepatic Tropism.

Billingsley, Margaret M; Gong, Ningqiang; Mukalel, Alvin J; Thatte, Ajay S; El-Mayta, Rakan; Patel, Savan K; Metzloff, Ann E; Swingle, Kelsey L; Han, Xuexiang; Xue, Lulu; Hamilton, Alex G; Safford, Hannah C; Alameh, Mohamad-Gabriel; Papp, Tyler E; Parhiz, Hamideh; Weissman, Drew; Mitchell, Michael J.

Small ; 20(11): e2304378, 2024 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-38072809

7.

Modified E2 Glycoprotein of Hepatitis C Virus Enhances Proinflammatory Cytokines and Protective Immune Response.

Vijayamahantesh, Vijayamahantesh; Patra, Tapas; Meyer, Keith; Alameh, Mohamad-Gabriel; Reagan, Erin K; Weissman, Drew; Ray, Ranjit.

J Virol ; 96(12): e0052322, 2022 06 22.

Artigo em Inglês | MEDLINE | ID: mdl-35612312

8.

Nucleoside-Modified mRNA Vaccines Protect IFNAR^-/- Mice against Crimean-Congo Hemorrhagic Fever Virus Infection.

Appelberg, Sofia; John, Lijo; Pardi, Norbert; Végvári, Ákos; Bereczky, Sándor; Ahlén, Gustaf; Monteil, Vanessa; Abdurahman, Samir; Mikaeloff, Flora; Beattie, Mitchell; Tam, Ying; Sällberg, Matti; Neogi, Ujjwal; Weissman, Drew; Mirazimi, Ali.

J Virol ; 96(3): e0156821, 2022 02 09.

Artigo em Inglês | MEDLINE | ID: mdl-34817199

9.

The Unexpected Importance of the Primary Structure of the Hydrophobic Part of One-Component Ionizable Amphiphilic Janus Dendrimers in Targeted mRNA Delivery Activity.

Zhang, Dapeng; Atochina-Vasserman, Elena N; Lu, Juncheng; Maurya, Devendra S; Xiao, Qi; Liu, Matthew; Adamson, Jasper; Ona, Nathan; Reagan, Erin K; Ni, Houping; Weissman, Drew; Percec, Virgil.

J Am Chem Soc ; 144(11): 4746-4753, 2022 03 23.

Artigo em Inglês | MEDLINE | ID: mdl-35263098

10.

Rational Design of Bisphosphonate Lipid-like Materials for mRNA Delivery to the Bone Microenvironment.

Xue, Lulu; Gong, Ningqiang; Shepherd, Sarah J; Xiong, Xinhong; Liao, Xueyang; Han, Xuexiang; Zhao, Gan; Song, Chao; Huang, Xisha; Zhang, Hanwen; Padilla, Marshall S; Qin, Jingya; Shi, Yi; Alameh, Mohamad-Gabriel; Pochan, Darrin J; Wang, Karin; Long, Fanxin; Weissman, Drew; Mitchell, Michael J.

J Am Chem Soc ; 144(22): 9926-9937, 2022 06 08.

Artigo em Inglês | MEDLINE | ID: mdl-35616998

11.

Lipid-nanoparticle-encapsulated mRNA vaccines induce protective memory CD8 T cells against a lethal viral infection.

Knudson, Cory J; Alves-Peixoto, Pedro; Muramatsu, Hiromi; Stotesbury, Colby; Tang, Lingjuan; Lin, Paulo J C; Tam, Ying K; Weissman, Drew; Pardi, Norbert; Sigal, Luis J.

Mol Ther ; 29(9): 2769-2781, 2021 09 01.

Artigo em Inglês | MEDLINE | ID: mdl-33992803

12.

Human Cytomegalovirus Glycoprotein B Nucleoside-Modified mRNA Vaccine Elicits Antibody Responses with Greater Durability and Breadth than MF59-Adjuvanted gB Protein Immunization.

Nelson, Cody S; Jenks, Jennifer A; Pardi, Norbert; Goodwin, Matthew; Roark, Hunter; Edwards, Whitney; McLellan, Jason S; Pollara, Justin; Weissman, Drew; Permar, Sallie R.

J Virol ; 94(9)2020 04 16.

Artigo em Inglês | MEDLINE | ID: mdl-32051265

13.

A Multi-Targeting, Nucleoside-Modified mRNA Influenza Virus Vaccine Provides Broad Protection in Mice.

Freyn, Alec W; Ramos da Silva, Jamile; Rosado, Victoria C; Bliss, Carly M; Pine, Matthew; Mui, Barbara L; Tam, Ying K; Madden, Thomas D; de Souza Ferreira, Luís Carlos; Weissman, Drew; Krammer, Florian; Coughlan, Lynda; Palese, Peter; Pardi, Norbert; Nachbagauer, Raffael.

Mol Ther ; 28(7): 1569-1584, 2020 07 08.

Artigo em Inglês | MEDLINE | ID: mdl-32359470

14.

Evaluation of the immunogenicity of an mRNA vectored Nipah virus vaccine candidate in pigs.

Pedrera, Miriam; McLean, Rebecca K; Medfai, Lobna; Thakur, Nazia; Todd, Shawn; Marsh, Glenn; Bailey, Dalan; Donofrio, Gaetano; Muramatsu, Hiromi; Pardi, Norbert; Weissman, Drew; Graham, Simon P.

Front Immunol ; 15: 1384417, 2024.

Artigo em Inglês | MEDLINE | ID: mdl-38726013

15.

An electrochemiluminescence assay for gp340 (DMBT1).

Barber, Cheryl; Weissman, Drew; Barnhart, Kurt; Dalvi, Minal; Abrams, William R; Malamud, Daniel.

Anal Biochem ; 440(1): 78-80, 2013 Sep 01.

Artigo em Inglês | MEDLINE | ID: mdl-23727557

16.

Ligand-tethered lipid nanoparticles for targeted RNA delivery to treat liver fibrosis.

Han, Xuexiang; Gong, Ningqiang; Xue, Lulu; Billingsley, Margaret M; El-Mayta, Rakan; Shepherd, Sarah J; Alameh, Mohamad-Gabriel; Weissman, Drew; Mitchell, Michael J.

Nat Commun ; 14(1): 75, 2023 01 17.

Artigo em Inglês | MEDLINE | ID: mdl-36650129

17.

Targeted Nanocarriers Co-Opting Pulmonary Intravascular Leukocytes for Drug Delivery to the Injured Brain.

Nong, Jia; Glassman, Patrick M; Myerson, Jacob W; Zuluaga-Ramirez, Viviana; Rodriguez-Garcia, Alba; Mukalel, Alvin; Omo-Lamai, Serena; Walsh, Landis R; Zamora, Marco E; Gong, Xijing; Wang, Zhicheng; Bhamidipati, Kartik; Kiseleva, Raisa Y; Villa, Carlos H; Greineder, Colin Fred; Kasner, Scott E; Weissman, Drew; Mitchell, Michael J; Muro, Silvia; Persidsky, Yuri; Brenner, Jacob Samuel; Muzykantov, Vladimir R; Marcos-Contreras, Oscar A.

ACS Nano ; 17(14): 13121-13136, 2023 07 25.

Artigo em Inglês | MEDLINE | ID: mdl-37432926

18.

Ionizable Lipid Nanoparticles for Therapeutic Base Editing of Congenital Brain Disease.

Palanki, Rohan; Bose, Sourav K; Dave, Apeksha; White, Brandon M; Berkowitz, Cara; Luks, Valerie; Yaqoob, Fazeela; Han, Emily; Swingle, Kelsey L; Menon, Pallavi; Hodgson, Emily; Biswas, Arijit; Billingsley, Margaret M; Li, Li; Yiping, Fan; Carpenter, Marco; Trokhan, Alexandra; Yeo, Julie; Johana, Nuryanti; Wan, Tan Yi; Alameh, Mohamad-Gabriel; Bennett, Frederick Chris; Storm, Phillip B; Jain, Rajan; Chan, Jerry; Weissman, Drew; Mitchell, Michael J; Peranteau, William H.

ACS Nano ; 17(14): 13594-13610, 2023 07 25.

Artigo em Inglês | MEDLINE | ID: mdl-37458484

19.

Rational design of anti-inflammatory lipid nanoparticles for mRNA delivery.

Zhang, Hanwen; Han, Xuexiang; Alameh, Mohamad-Gabriel; Shepherd, Sarah J; Padilla, Marshall S; Xue, Lulu; Butowska, Kamila; Weissman, Drew; Mitchell, Michael J.

J Biomed Mater Res A ; 110(5): 1101-1108, 2022 05.

Artigo em Inglês | MEDLINE | ID: mdl-35076171

20.

Amniotic fluid stabilized lipid nanoparticles for in utero intra-amniotic mRNA delivery.

Swingle, Kelsey L; Billingsley, Margaret M; Bose, Sourav K; White, Brandon; Palanki, Rohan; Dave, Apeksha; Patel, Savan K; Gong, Ningqiang; Hamilton, Alex G; Alameh, Mohamad-Gabriel; Weissman, Drew; Peranteau, William H; Mitchell, Michael J.

J Control Release ; 341: 616-633, 2022 01.

Artigo em Inglês | MEDLINE | ID: mdl-34742747

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